Endocrine Abstracts

Aim: The aim of this study was to compare clinical symptoms and TSH receptor antibodies (TRAb) in Graves orbitopathy (GO) in hyperthyroid patients to those patients with primarily hypothyroid and euthyroid status.Methods: Study group consisted of 54 primarily hyperthyroid (39 female, 14 male, 47±9 years) and 8 primarily hypothyroid and euthyroid patients (5 female, 3 male, 46±14 years). Clinical symptoms and TRAb were assessed. Assessment of th...

Background/objectives: The aim of the study was to assess association between diabetes mellitus (DM) and arterial hypertension (AH) in patients with adrenal incidentaloma.Design and methods: One hundred and eleven consecutive patients with incidentally discovered adrenal tumours were included in the study. OGTT was done and 24 h urinary catecholamines were measured. Aldosterone and plasma renine activity (PRA) were determined, and 1 mg dexametasone test ...

Background: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disease that occurs in about 10% of women in reproductive age. Today, PCOS is considered not only reproductive edocrinopathy but also a metabolic disorder associated with long-term health risks, including diabetes mellitus and cardiovascular disease.Objectives: The aim of this study was to evaluate the presense of early vascular demage in normal-weight women with polycystic ovar...

The aim of the study was to assess the influence of thyroid hormones on lipid profiles in primary hypothyroidism, in order to determine the most influential one for the clinical follow-up. Study group included 15 subjects (3 male, 12 female, age 46±13 years/mean±S.D.), and total and free T4, total and free T3 and TSH, total, HDL and LDL cholesterol, triglycerides, ApoA, ApoB and Lp(a) were determined. The diagnosis of primary hypothyroidism was based o...

Background: Hypothyroid Graves’ ophthalmopathy is a rare condition, present in about 3% of all cases. Since thyroid-stimulating antibodies could be detected in a majority of euthyroid and hypothyroid Graves’ patients, the most probable explanation for unincreased thyroid function is a reduction of tissue capability to response to stimulation.Case report: A 57-yr-old man visited the hospital with signs and symptoms typical of hypothyroidism. Sin...

Background: Women with polycystic ovary syndrome (PCOS) appear at increased cardiovascular risk due in part to a dyslipidemia characterized by increased plasma triglyceride and reduced high density lipoprotein (HDL) cholesterol levels. Insulin resistance is one of the features of PCOS and potentially affect lipid metabolism.Objectives: The aim of this study was to compare basal insulin levels and lipid profile in lean women with PCOS with weight matched ...

Background: Thyroid function regulates a wide array of metabolic parameters and significantly affects lipoprotein metabolism. Subclinical hypothyroidism (SCH) is the most common thyroid disorder, with a prevalence up to 10% in adult populations. Subclinical hypothyroidism is defined as mild elevation in thyroid stimulating hormones (TSH) in presence of normal free thyroxine (fT4) and free triiodothyronine (fT3). This mild elevation of serum TSH is caused by a minor initial dec...

Background: Ectopic Cushing’s syndrome (ECS) frequently represents a diagnostic challenge due to its complex clinical presentation.Case presentation: A 57-year-old male presented with typical Cushingoid appearance, high adrenocorticotropic hormone (ACTH) level (138.3 pg/ml), lack of cortisol circadian rhythm and suppression in overnight 1 mg dexamethasone suppression test (DST) (1374 nmol/l). Great daily fluctuation of serum cortisol levels from ver...

Graves’ disease (GD) is an autoimmune disease that can affect other tissues in addition to the thyroid gland. Depending on the intensity of the immune response, in addition to hyperthyroidism, orbitopathy, dermatopathy and acropachy can also occur. Extrathyroidal manifestations of GD are most often the result of a more pronounced immune response. Thyroid dermatopathy (TD) is a rare extrathyroidal manifestation of GD, almost always associated with Graves’ orbitopathy ...

Background: Thyroid hormones have regulatory effect on serotonin and noradrenaline and thyroid dysfunction is closely linked to some mental disorders. Besides depression and anxiety, and increased risk for suicide is demonstrated in patients with Graves’ disease (GD).The aim: of our research was to determine the symptomatology of depression in patients with hyperthyroidism and Graves’ orbitopathy (GO) and compare it with hyperthyroid patients w...